CAR T-Cell Therapy cost in India

CAR T-cell therapy cost in India can range from $45000 to $85000, which is equivalent to approximately 38,50,000 to 75,00,000 Indian rupees. CAR T-cell therapy is an advanced treatment where a patient's T cells, which are crucial to the immune system, are altered in a lab to specifically target and destroy cancer cells.

The process begins with extracting T cells from the patient's blood, which are then genetically engineered to display chimeric antigen receptors (CARs) on their surface. After modification, these CAR T cells are multiplied in the lab and reintroduced into the patient's body via infusion. This therapy is uniquely personalized for each patient and has shown great success in treating difficult cancers like leukemia and lymphoma. Ongoing research explores its potential to treat other cancer types.


Cost Range of CAR T-Cell Therapy cost in India

Minimum Cost USD 45000
Maximum Cost USD 85000
Total Stay 30 Days
Hospital Stay 5 Days

Cost Inclusions:

  • CAR T-cell therapy development

  • Lab charges

  • Hospital stay for recommended days

  • Airport pick up and drop

  • Doctor's fee and consultation

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CAR T-cell therapy offers the advantage of a shorter treatment duration compared to traditional cancer therapies. It provides long-term remission and an improved quality of life for patients, often surpassing conventional approaches. Unlike stem cell transplants, which involve intensive chemotherapy, CAR T-cell therapy generally results in a quicker recovery for most patients.

Additionally, CAR T-cells differ from Tumor Infiltrating Lymphocytes (TILs) and T Cell Receptors (TCRs) as they do not rely on Major Histocompatibility Complex (MHC) expression for antigen recognition. This unique ability allows CAR T-cells to recognize specific antigens independently of antigen processing by the target cells and MHC restrictions, leading to more effective tumor cell destruction.

Who is a candidate for CAR T-cell therapy in India?

In India, candidates for CAR T-cell therapy are typically patients with certain types of cancers that have not responded to conventional treatments, such as chemotherapy or radiation. The most common cancers for which CAR T-cell therapy is currently approved include:

Relapsed or Refractory Blood Cancers

Patients with certain types of blood cancers, such as B-cell acute lymphoblastic leukemia (ALL) in children and young adults, and certain types of non-Hodgkin lymphoma (NHL) like diffuse large B-cell lymphoma (DLBCL), who have not responded to standard treatments, may be considered.

Eligibility Criteria

  • Disease Status: The patient should have relapsed or refractory disease after at least two prior lines of therapy.
  • Health Condition: The patient should be in a reasonably good health condition to withstand the treatment, as CAR T-cell therapy can cause side effects in certain patients, including cytokine release syndrome (CRS) and neurological toxicities.
  • Medical Evaluation: A thorough medical evaluation is conducted to assess whether the patient is a suitable candidate, including considering factors like the patient's overall health, comorbidities, and prior treatment history.
  • Availability: As CAR T-cell therapy is relatively new in India, it is mostly available through specialized cancer centers. Patients should consult with oncologists at institutions offering CAR T-cell therapy to determine if they are eligible.

Types of CAR T-Cell Therapy Treatment Cost

Type of FDA Approved CAR T-Cell Therapy in India

Diagnosis

Cost Range in USD

KymriahB-Cell Acute Lymphoblastic Leukemia (ALL)B-Cell Non-Hodgkin's Lymphoma (NHL)65000 - 85000
YescartaB-Cell Non-Hodgkin's Lymphoma (NHL)Follicular Lymphoma65000 - 85000
TecartusMantle Cell Lymphoma (MCL)B-Cell Acute Lymphoblastic Leukemia (ALL)65000 - 85000
BreyanziB-Cell Non-Hodgkin's Lymphoma (NHL)65000 - 85000
AbecmaMultiple Myeloma45000 - 65000
CarvyktiMultiple Myeloma45000 - 65000

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CAR T-Cell Therapy Cost in India Inclusions

  • CAR T-cell therapy infusions

  • Routine medicines and consumables required during treatment

CAR T-Cell Therapy Cost in India Exclusions

  • Pre-treatment examination and tests related to staging of cancer

  • Meals and flights

  • Hospital and hotel stay

  • Post-treatment follow-ups and management

  • Treatment for any other underlying medical conditions 

  • Any complex investigations or medicines

  • Anything not covered in the package 

Other Factors Affecting CAR T-Cell Therapy Cost in India

  • Age of the patient and symptoms

  • Type of blood cancer (how much it has spread)

  • Stage and grade of cancer

  • Pre-existing medical history 

  • Recommended treatment and duration

  • Number and type of treatment modalities advised

Diagnostic Tests Required Before CAR T-Cell Therapy Treatment

Types of Tests For CAR T-Cell Therapy Treatment in India

Cost Range in USD

Blood tests

These include the basic blood investigations for the patient to check organ functioning, infection status and coagulation profile.

50 to 100

Radiological Assessment

MRI, CT or any other tests to check for location of the disease. This may also include an endoscopic ultrasound (EUS).

150 to 250

Histopathology Examination

This includes tests such as biopsy for examination under a microscope.

150 to 250

Full Body PET Scan

This includes a full body PET FDG scan to check for an metastasis and establish the stage of the cancer.

400 to 600

Assessment for Cytokine Release Syndrome (CRS)Although not a diagnostic test, understanding the risk of CRS and preparing for its management is crucial. Cardiac and pulmonary assessment is also planned alongside.100 to 150

Why is India preferred as one of the best countries for CAR T-Cell Therapy Treatment?

India is becoming a preferred destination for CAR T-cell therapy due to several compelling reasons. The treatment is often more cost-effective in India compared to Western countries, making it accessible to a broader range of patients. Additionally, India boasts advanced medical facilities equipped with state-of-the-art technology and skilled professionals who specialize in CAR T-cell therapy.

Indian oncologists have extensive experience and expertise gained through global collaborations and research, ensuring high-quality care. Comprehensive patient care, including thorough pre-treatment evaluations, personalized treatment plans, and robust post-treatment support, is a hallmark of Indian hospitals. The country also serves as a hub for clinical trials, providing access to the latest therapies. Furthermore, India offers multilingual services and patient-centric care, which are advantageous for international patients. Favorable regulations and streamlined processes for medical visas and treatment approvals further facilitate access to this advanced treatment. These factors collectively enhance India's reputation as a leading destination for CAR T-cell therapy.

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